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Since the body cannot produce B12 on its own, it must be obtained through diet (found in animal products) or supplements, such as B12 injections

The NHLBI iron deficiency anemia reference confirms ferritin and transferrin saturation as the supporting diagnostic markers

The 46 hour offset balances NAD+ availability with receptor readiness

[1] Observational studies and case reports have documented acne flares temporally associated with B12 supplementation, particularly following high-dose intramuscular injections

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Nicotinamide N-methyltransferase: At the crossroads between cellular metabolism and epigenetic regulation