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The criteria for protein identification included (1) a calculated false discovery rate 39 below 1%, (2) all the proteins must have been identified with more than two unique peptides and (3) all peptide signals (heavy/light isotope labelling) for each protein must have at least a fourfold enrichment in FUS/TLS immunoprecipitates compared with the LAP control (purified from the parental HeLa cell line)

For structural alignments, if possible, crystal structures otherwise AlphaFold3 models were used

Drug Des Devel Ther 14691495

[DOI] [PMC free article] [PubMed] [Google Scholar] 31.Tian L.-W., Luo D., Chen D., Zhou H., Zhang X.-C., Yang X.-L., Wang Y.-L., Liu W

allometric exponent on CL = 0.8 (BW^0.8)