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The research protocol was performed with the approval of the Ethics Committee of Harbin Institute of Technology (Approval No: HIT-2022008)

This means that the clinical effectiveness of GSHand that of its precursors like NACis dependent not only on its capability to act as an antioxidant, but also the degree to which their pharmacodynamic properties are in line with the dysfunction in cellular signaling, redox imbalance, and immune response generated by specific disease states (Chai and Mieyal, 2023

The remaining three studies reported GSH level decreases with age, in particular, (a) decreases in old versus young adults in the precuneus and the posterior cingulate at 3T (Suri et al., 2017), and the occipital cortex at 4T (Emir et al., 2011), and (b) a negative correlation with age in the medial pregenual anterior cingulate cortex in young to middle-aged adults (2054 yrs) at UHF (7T) (Lally et al., 2016)

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