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We have adapted these recommendations into 10 updated research recommendations: five on evidence for existing treatments and five related to novel treatments and disease understanding (table 3)

To circumvent solubility problems, especially when additionally modifying the PNA with hydrophobic linkers (e.g

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Moreover, NO seems to be the only mediator of cell proliferation arrest through the ERK1/2-p53 signaling pathway ( FIGURE 1 Next to this evidence, in our laboratory it has been demonstrated that GSH depletion modulates the peroxisome proliferator-activated receptor gamma, co-activator 1 alpha (PGC-1) expression and its downstream metabolic pathway in neuronal and skeletal muscle cells ( Figure 1 )