Frontiers
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glutathione increase platinum drugs The Next Generation of Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs Frontiers | Glutathione-responsive and -exhausting
Description
Chowdhury et al., 2022
S., Kjuus, H., Zienolddiny, S., Haugen, A
[DOI] [PMC free article] [PubMed] [Google Scholar] 122.Alkadi H
The structural data also revealed the molecular mechanism of SAM activation, whereby the Bateman module in the RD acts as an autoinhibitory cap to the CD, and upon binding SAM, undergoes a conformational change relieving the inhibition to allow active site access for catalysis (Supplementary Fig
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