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Furthermore, ROS can cause the activation of apoptotic pathways (Cashman and Hoke, 2015) and increase production of pro-inflammatory mediators (Bulua et al., 2011)

Genes related to ferroptosis were found to be differentially expressed in microglia after SCI, with the most significant changes in Stmn1 and Fgfbr1

Avoiding Excess IGF-1 Levels While elevated IGF-1 is beneficial for recovery, metabolism, and body composition, chronically supra-physiologic IGF-1 can carry risks, including potential links to accelerated cellular aging and increased cancer risk in certain populations

In contrast, during dysbiosis and BV, there is a restriction in the population of Lactobacilli , leading to a reduction in lactic acid levels

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