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Long-term use of metformin and its effect on serum vitamin B12 with its oral manifestations: a review

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LIHC is characterized by a series of metabolic alterations such as increased glucose uptake and lactate production [91, 92], upregulated de novo lipogenesis and NADPH production [93, 94], accelerated glutamine consumption [95], elevated amino acids metabolism, and GSH synthesis [9699], as well as attenuated TCA cycles and fatty acid -oxidation [93, 100, 101] when compared with the non-cancerous sample tissues [102]

While there is no established link between these medications and structural changes to taste buds themselves, the functional experience of taste can be significantly modified during treatment, impacting dietary preferences and eating behaviors in ways that may contribute to the therapeutic effects of these agents

Early signs of declining B12 levels include profound fatigue, tingling or numbness in extremities, cognitive changes, and balance problems requiring medical review

Weekly Dosing Schedule for the First Month After the first week, a weekly dosing schedule is used for the next month