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Resistance a major hindrance to chemotherapy in hepatocellular carcinoma: An insight

Knockdown of pdr-1 plus the addition of all three stressors produced a more severe degeneration phenotype than any two stressors alone (Figure 4a) whereas, with similar conditions, further enhancement of neurodegeneration was not observed in pink-1 (RNAi) animals (Figure 4b)

Girardi, E

Compared to oral and intravenous administration, pulmonary drug delivery has the advantages of local lung targeting, high local drug concentration and rapid onset of action, low systemic distribution and toxicity, avoided degradation in the gastrointestinal tract and hepatic firstpass metabolism, and good patient compliance without using needles [4, 5]

Neurotoxicology , 44, 61-70

[10] Apart from acting as a precursor to glutathione, n-acetylcysteine has also been shown to scavenge reactive oxygen species directly