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doi: 10.1007/s10875-010-9488-0 144 ShirohzuHKubotaTKumazawaASadoTChijiwaTInagakiKet al

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Approach Phase 2b trial arm Duration 24 weeks Review Point Week 12 and 24 Notes METAOD006 (OPTIONS) used 24 weeks at oral doses 0.25, 0.5, or 1 mg/day in 502 obese adults

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Research in animal models shows activity at approximately 0.5mcg/kg, though human protocols typically use standardized doses in the 1-3mg range regardless of body weight

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