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Chronic Kidney Disease Chronic Kidney Disease Last Section Update: 12/2025 Contributor(s) : Maureen Williams, ND

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Notable recent developments include the first preclinical study demonstrating NNMT inhibition improves cardiac function and reduces fibrosis in a heart failure model (Li et al., 2025), a comprehensive review of NNMT as a therapeutic target for neurodegenerative disorders (Liu et al., 2025), and emerging evidence that NNMT inhibition counteracts tubular senescence and fibrosis in chronic kidney disease

By attributing equal weight to all measures in the proposed measure set, Option 5 satisfies the minimal weight criterion for Improvement in Dyspnea

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Jansen et al., 2018) fall within the human range of 8781,170 mg/day