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The animal science is genuinely interesting

Marelja, Z

3 Results 3.1 Macrophage infection by HIV via cell-to-cell contact depends on viral tropism, macrophage polarization, and impairs osteoclast differentiation To investigate the determinants of HIV transmission from infected CD4+ T lymphocytes to macrophages (Mf), PBMC-derived Mf were first polarized into M0, M1, or M2 phenotypes and then co-cultured with Jurkat (Jk) cells: mock-infected (Jk-Mock), infected with R5- (Jk-R5) or X4-tropic (Jk-X4) HIV strains (see experimental timeline in Supplementary Figure S1A ), harboring comparable infection rate (25.5 2.7% and 24.0 6.4%, respectively

This study of mouse hybridomas provides strong evidence that allelic inclusion of Tcrd occurs frequently

Importantly, miRNAs can be transported between cancer cells and stromal cells through extracellular vesicles known to mediate cell-to-cell communication in the tumor microenvironment ( in vitro and angiogenesis and metastasis of breast cancer in vivo (Zhou et al., 2014)

Merlino et al., 2023)