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doi: 10.1038/s41579-022-00712-1 184 WeinstockG

The high affinity of A Fe 3+ , Cu 2+ and Zn 2+ , caused its aggregation and oligomerization

Both losses of normal cellular function and gain of aberrant toxic functions (or both together) are implicated as pathogenic mechanisms in ALS, depending on the protein involved

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Badran, M., Morsy, R., Soliman, H

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