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Dual Agonism and Metabolic Regulation Cagrilintides mechanism of action involves dual agonism of amylin and calcitonin receptors

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developed an electrospun DegraPol tube delivering secretome from a co-culture of adipose-derived stem cells and tenocytes for Achilles tendon repair in rabbits, showing that this cell-free implant significantly reduced adhesion formation (22%), lowered tendon swelling (32% cross-sectional area), and restored near-native load and stiffness, demonstrating its strong potential as a biodegradable, secretome-releasing scaffold to enhance tendon healing and biomechanics (Rieber et al., 2025)

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