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While directly measuring neuroprotection in living patients is technically unfeasible, alternative strategies, such as monitoring pro-inflammatory markers or neuroprotective cytokines in the plasma of patients receiving istradefylline, could offer valuable mechanistic insights and serve as surrogate indicators of therapeutic activity [485]

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This is called rebound hyperpigmentation, caused by suppressed melanin suddenly over-producing

Interestingly, no associations were observed for GSH changes in buccal cells

56 Besides, at the single-cell level, it is likely that tumor cells, immune cells, and stromal cells within the TME, which encounter more severe oxygen deprivation, tend to upregulate both glycolysis and mitochondrial OXPHOS

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