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Accordingly, these principles have been therapeutically exploited in nanomedicine platforms designed to induce GSH-dependent ROS amplification (Fig
2008 [12] Moriarty SE et al
J Biol Chem 277:4350511 Okamoto T, Akaike T, Sawa T, Miyamoto Y, van der Vliet A, Maeda H (2001) Activation of matrix metalloproteinases by peroxynitrite-induced protein S -glutathiolation via disulfide S -oxide formation

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