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PHGDH, the first SSP enzyme, is markedly upregulated in HCT-116 colon cancer cells, in contrast to normal colonic epithelial cells, which exhibit only basal levels of expression

Acta Crystallogr D Biol Crystallogr 60:12201228 McDowell JV, Frederick J, Miller DP, Goetting-Minesky MP, Goodman H, Fenno JC, Marconi RT (2011) Identification of the primary mechanism of complement evasion by the periodontal pathogen, Treponema denticola

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Notably, its synergy with EGFR tyrosine kinase inhibitors in NSCLC highlights its value in combination therapies

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The effect of an oral anti-oxidant, N-Acetyl-cysteine, on inflammatory and oxidative markers in pulmonary sarcoidosis
