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Apolipoprotein E (APOE) is a multifunctional protein expressed by various cell types, including hepatocytes, adipocytes, immune cells of the myeloid lineage, vascular smooth muscle cells, astrocytes, etc
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Chronic administration of AOD9604 in obese mice and rats leads to significant reductions in body weight gain and increases in fat oxidation, without the adverse effects on insulin sensitivity seen with full-length hGH treatment [3][4]

Methylcobalamin is an active form of vitamin B12 that helps in synthesis of methionine and S-adenosylmethionine

Aging-associated cellular senescence and stem cell exhaustion inhibit adipocyte renewal, leading to excessive hypertrophy and low-grade inflammation
