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The upregulation of autophagy levels can cause the overexpres-sion of the NCOA4 gene, and NCOA4 can cause iron storage as a cargo receptor

This potentially diminished ability to regenerate energy levels is reflective of the delayed or even lack of recovery from fatigue, one of the multiple symptoms of post-exertional malaise (PEM), exacerbated by physical or mental exertion in ME/CFS (7, 35)

Kakkar RK, Berry RB

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Research suggests that a flavonoid glucoside extracted from E

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