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In the Schneider-Helmert crossover trial, researchers noted no evidence of tolerance across the treatment period and no rebound insomnia after discontinuation two issues that commonly limit long-term use of benzodiazepines and Z-drugs

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Preclinical evidence also suggests disease-modifying potential: ashwagandha reduced -amyloid plaque accumulation, inhibited tau hyperphosphorylation, and controlled microglial overactivation, effects that may slow Alzheimers pathology [28,29]

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