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In addition to its pro-differentiating actions, nicotinamide promotes neuronal survival, especially in oxidative stress environments, through various pathways, such as maintenance of protein kinase B (akt)-dependent phosphorylation of forkhead transcription factor (FOXO3a)

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Because AOD 9604 does not bind the growth hormone receptor, it does not trigger the IGF-1 cascade

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Also searched were the Cochrane database and the National Guideline Clearinghouse database