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The bdomain provides the principal peptide-binding site of protein disulfide isomerase but all domains contribute to binding of misfolded proteins

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Interestingly, when the M pro concentration was increased to 18 M it was largely resistant to GSSG inhibition, with no inhibition observed with 2 mM GSSG and less than 20% inhibition with 10 mM GSSG (Figure 1B)

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References Blher M

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