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Environmental temperature manipulations For both acute and chronic thermal exposure experiments, mice were housed in temperature-controlled chambers (RIS77SD Rodent Incubator, Power Scientific Inc.) set to cold (4 C or 10 C), room (22 C), or warm (28 C or 30 C) ambient temperatures, depending on the experimental condition

Each of these scales was analyzed separately using one effect per study at the end-of-treatment time point

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12 Inflammation is likely to last for one to two weeks after treatment has finished

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