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PD-L1 is a transmembrane protein normally expressed on the surface of some macrophages, DCs, and activated T and B cells

Peroxisome proliferators activator receptors gamma (PPAR) has been reported to effectively suppress cancer progression.132 When treated with Keap1 shRNA, PPAR of the nonsmall cell lung cancer (NSCLC) cells increase, and cells were more susceptible to arsenic trioxide, etoposide, and doxorubicin, suggesting that Nrf2 contributes to drug resistance by the downregulation of PPAR.133 To summarize, when Nrf2 is overactivated in cancer cells, specific antioxidant enzymes, phase II enzymes, and transporters are excessively expressed

Skerra, A., Pfitzinger, I

Epub 2020 Feb 22

Hall, I

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