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Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntington's disease mice

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Interestingly, ursodeoxycholic acid, the only treatment approved by the Food and Drug Administration for the treatment of primary biliary cirrhosis, a chronic cholestatic disorder, was shown to prevent the fall in GCL expression during chronic cholestasis (Serviddio et al., 2004) and increase GCL expression in cultured rat hepatocytes (Mitsuyoshi et al., 1999)