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Neuron 72, 257268

Single-stranded DNA damage negatively affects the normal replication machinery [36]

The concomitant administration of -tocotrienol has demonstrated an increased efficacy of gemcitabine (88), and a phase I study on pancreatic cancer patients was conducted with escalating doses of -tocotrienol in the 2 weeks before surgery (91)

Summer considerations Higher ambient temperatures mean your refrigerator works harder, and any time a vial spends outside the fridge is more dangerous

STEP 1 - non-diabetic obesity trial at 2.4 mg

Both ALT and AST require PLP for their activity