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For other cancer entities including bladder cancer and oral cavity carcinoma, a downregulation of ODC1 by DNA hypermethylation and subsequently global demethylation has been reported [70,71]

The zinc sensing receptor, ZnR/GPR39, triggers metabotropic calcium signalling in colonocytes and regulates occludin recovery in experimental colitis

Hippocampal-dependent spatial memory performance, as measured by the spontaneous alternation in the Y-maze, was positively correlated with hippocampal concentrations of NAA ( r = 0.36, p = 0.024) and glutamate ( r = 0.40, p = 0.014), but not with hippocampal concentrations of GABA ( r = 0.06, p = 0.373) (Figure 2B)

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Senolytics Among the first senolytic agents discovered was a combination therapy consisting of Dasatinib (D

Helv Chim Acta 87(2):317326 French JA, Koepp M, Naegelin Y et al (2017) Clinical studies and anti-inflammatory mechanisms of treatments