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In humans, the half-life of cobalamin is approximately one year, and in the case of cobalamin malabsorption, clinical signs occur after several years

Higher doses may be considered under clinical supervision for those who decline injections despite malabsorption, though this is an off-label approach

Mood stabilization represents another potential benefit

This highly reactive compound can cause lipid peroxidation and destabilization of cell membranes, DNA damage, and subsequent activation of the DNA repair enzyme poly (ADP-ribose) polymerase (PARP) leading to cellular energy collapse and death (48, 50)

Preventative health and wellness are at the heart of everything we do

American Journal of Clinical Nutrition 2011;94(4):107987