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( Figure S1 ) Risk of bias was evaluated separately for efficacy and safety outcomes

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Given that -arrestin2 is a scaffolding protein, we further examined the interaction between -arrestin2 and PKM2

Abbreviations AAA: Abdominal aortic aneurysm ABDF: Aminosulfonyl)-7-fluoro-2,1,3benzoxadiazole ADMA: Asymmetric dimethylarginine ATP: Adenosine tri phosphate BPHL: Biphenyl hydrolase-like protein CO: Carbon monoxide CSE: Cystathionine--lyase CVD: Cardiovascular disease Cys: Cysteine CS: Cystathionine beta synthase e-NOS: Endothelial nitric oxide synthase ESRD: End stage renal disease H 2 S: Hydrogen sulfide Hcy: Homocysteine HHcy: Hyperhomocysteinemia HPLC: High performance liquid chromatography HTL: Homocysteine thiolactone IR: Insulin resistance LDL: Low density lipoprotein Lys: Lysine Met: Methionine MI: Myocardial infarction NAC: N-acetyl cysteine NO: Nitric oxide PD: Parkinsons disease PON: Paraoxonase PRMT: Protein arginine N-methyltransferase SAH: S-adenosyl-L-homocysteine SAM: S-adenosyl-L-methionine tHcy: Total homocysteine References McCully KS

Glutathione Transferase A1-1: Catalytic Importance of Arginine 15

Scopes of nature-derived compounds in modulating Nrf2/Keap1/ARE axis It has already been discussed that for chemotherapeutic activities, Nrf2 needs to be inhibited while to prevent cancer initiation and recurrence, Nrf2 cascade needs to be activated