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Neelakantan H, Wang H-Y, Vance V, Hommel JD, Mchardy SF, Watowich SJ (2017) Structure-activity relationship for small molecule inhibitors of nicotinamide N -Methyltransferase

This phenomenon, known in medical literature as the "Folate Trap", creates a functional deficiency where the cell starves for active folate even if there is plenty of it circulating in the blood (though the cited source actually discusses the nutritional value of plant-based diets in relation to human amino acid requirements)

for those with neurological involvement, 1 mg on alternate days until no further improvement

Low levels may be a natural occurrence in some people but mostly levels decrease as we age

Its worth noting, though, that shared search interest doesnt reflect a validated combination protocol

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