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Description
Stocchi, V., Cucchiarini, L., Canestrari, F., Piacentini, M

R 4 is methylene and R 5 is absent

Methods: Authors used a computer-based gene profiling tool, The Connectivity Map, to identify a number of human genes regulated by GHK, relevant to regulation of cell differentiation, apoptosis and stem cell function

In pathological conditions, Tumor necrosis factor- (TNF-), which is a pro-inflammatory cytokine, has been reported to decrease the expression of both GLAST [144] and GLT-1 proteins, through activation of the NF-B and YY1 transcription factors [145,146]

opening mitochondrial permeability transition pores (MPTP) [90]

Both substances are linked to leukoencephalopathy
