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Briefly, adult animals were maintained on NGM RNAi plates with FUdR throughout life

FIGURE 9 Histological examination of pancreatic tissues revealed marked ethanol-induced pathological alterations, including disruption of the islets of Langerhans, degenerative changes in pancreatic acini, peri-ductal inflammation, neutrophil infiltration, interstitial edema and necrosis (Figures 10AE)

10.1084/jem.20122220 [DOI] [PMC free article] [PubMed] [Google Scholar] Mocsai A., Abram C

8-oxo-dG is one of the most frequently studied DNA oxidation products and results from the interaction between guanine and the hydroxyl radical ( OH), which originates, for example, from the Fenton reaction (see above) (Fig