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Older adults are generally at higher risk of B12 deficiency due to decreased absorption capacity

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10.1182/blood-2009-08-239525 138 SelhubJ.JacquesP

As such it is common for an affected patient to have inherited two different mutations, one from their mother and one from their father - these are referred to as compound heterozygotes

Interestingly, the degree of methylation correlated with the grade of tumor (Schuebel et al., 2005

Unveiling mitochondria as central components driving cognitive decline in Alzheimers disease through cross-transcriptomic analysis of hippocampus and entorhinal cortex microarray datasets