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In renal lesions, IL-1 has been shown to induce alterations in renal tissue structure by modulating the proliferation of thylakoid cells and the synthesis of matrix, as well as by increasing vascular endothelial cell permeability

At ~504 Da molecular weight with only two amino acid residues (Tyr-Ile core), it falls below the typical size range of bioactive peptides

Franz diffusion cell and its implication in skin permeation studies

Huth TK, Eaton-Fitch N, Staines D, Marshall-Gradisnik S

Jegatheesan P, Beutheu S, Ventura G, Sarfati G, Nubret E, Kapel N, Waligora-Dupriet AJ, Bergheim I, Cynober L, De-Bandt JP (2016) Effect of specific amino acids on hepatic lipid metabolism in fructose-induced non-alcoholic fatty liver disease

This should pave the way for more research and more regulated quality peptides worldwide, so that you, the users, can make informed decisions