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Using in vitro human models, we showed that these thiomethyl metabolites are directly linked to NAPQI detoxification since they are mainly formed after exposure to glutathione-derived conjugates via an overlooked pathway called the thiomethyl shunt

Tumor Suppression: In rats with M-1 sarcoma, it inhibited tumor growth and induced "hemorrhagic necrosis" of the tumor mass

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Objective: Lung cancer is the most common cause of cancer-related deaths worldwide

Renewed interest has uncovered strong ties to the immune sys