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Given that glial and neuronal cells undergo aging-related changes, including SASP, alterations in extracellular matrix composition, mitochondrial DNA release, and activation of inflammatory signaling pathways, shifts in membrane or lipid environments may influence these processes by modulating LLPS and domain dynamics

ROS initiate lipid peroxidation, alter protein structure, enhance the release of arachidonic acid from cell membranes, increase the synthesis and release of chemoattractants, and induce the release of tachykinins and neurokinins 14,15

Fine-tuning the cardiac O-GlcNAcylation regulatory enzymes governs the functional and structural phenotype of the diabetic heart

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Archived from the original on 18 April 2022