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Rev Bras Cir Cardiovasc 24:279288 Ortoleva J et al (2020) Vasoplegia during cardiopulmonary bypass: current literature and rescue therapy options

Vitamin B12, also known as cobalamin, is a vital nutrient with significant importance for various bodily functions

Many people choose to have vitamin B12 injections as they can play a crucial role in maintaining optimal health, especially for individuals who have conditions or deficiencies that hinder proper absorption of this essential nutrient

The position this article takes, given those three valid critiques, is that the mechanism evidence is strong enough, the delivery evidence is biologically plausible enough, and the safety window is wide enough that the recommendation is defensible

This is called physical dependence

Neither compound has established long-term human safety data