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The nuclear sensor of ROS, checkpoint kinase 1 (CHK1)-C408, which refers to the oxidative modification of the CHK1 protein at position C408, modulates the expression of single-stranded DNA binding protein 1 (SSBP1), an active mtDNA-binding protein in the mitochondria, and regulates nuclear H 2 O 2 levels by controlling mitochondrial translation(Zhang 2023)

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This includes vitamin C, retinoids at high concentrations, and low-pH chemical exfoliants

The data revealed that the sulforaphane derivative synthesized by introducing the benzyl group at the side chain of sulforaphane (benzyl sulforaphane) showed enhanced anticancer activity than any other derivative and SFN itself

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