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TFA treatment specifically increased the abundance of Streptococcus, Streptococcus, pneumoniae, and Staphylococcus epidermidis (Figure 3D)

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In addition, increasing neutrophils may contribute to the progression of AS through phagocytosis, ROS production damaging tissue and impairing endothelial function, repairing damaged tissues, restricting NET production, or directly releasing NET to counter inflammation, which may be beneficial for the progression of AS (32, 61, 203)

doi: 10.3892/ijo.2025.5730 173 LeeJWJPlichtaDHogstromLBorrenNZLauHGregorySMet al

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SFN functions by inhibiting and enhancing phase I enzymes interacting with cytochrome P450 and phase II enzymes by activating Nrf2 (Nuclear factor E2-factor related factor) (96) (Figure 2)