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Based on these mechanistic links, we propose that the gut microbiotahepatic ferroptosis axis may play a pivotal role in the pathogenesis of ALD

This study was supported by Liaoning Provincial Science and Technology Plan Project (2020JH2/10300118)

Studies with ALX5407, a selective GlyT1 inhibitor, have shown consistent results in neuropathic pain preclinical models induced by chronic constriction injury (CCI) (Hermanns et al

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Although the mechanisms destructive to pancreatic acinar cells are unknown, once a cellular injury pattern has been initiated, activated neutrophils exacerbate the problem by releasing superoxide (the respiratory burst) or proteolytic enzymes (cathepsins B, D, and G, collagenase and elastase)