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Oxidative imbalances (oxidative stress) in mitochondria promote the covalent modifications of lipids, proteins, and nucleic acids through enzymatic and non-enzymatic mechanisms

This study showed that PPE plus atorvastatin synergistically inhibited 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced lung tumorigenesis in mice and the growth of LC H1299 and H460 cells, probably by increased apoptosis [70]

Pacher, P., Beckman, J

Astragaloside IV prevents memory impairment in D-galactose-induced aging rats via the AGEs/RAGE/NF-B Axis