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The lipotropic agents (methionine, inositol, choline) are pH-sensitive and oxidise rapidly once exposed to air and moisture, which is why the 72-hour window exists rather than the 28-day stability window you'd see with straight methylcobalamin

[DOI] [PubMed] [Google Scholar] 190.Hatzimouratidis K., Amar E., Eardley I., Giuliano F., Hatzichristou D., Montorsi F., Vardi Y., Wespes E., European Association of U

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doi: 10.1074/mcp.RA118.001044, 128
