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Differentiation to DE stage downregulates mitochondrial biogenesis, regulators mitochondrial transcription factor A and, mtDNA polymerase- -1 and -2, which results in increased mitochondrial mass through upregulation of mtDNA transcription and replication (99, 100)

More thorough research is needed to prove the long-term efficacy of 5-HTP, but it may be a good natural depression treatment for people who do not respond well to SSRIs

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