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Hughes RA, Swan AV, van Doorn PA

e429 Shimizu K, Nihira NT, Inuzuka H, Wei W

This impairment would further exacerbate the disturbance of intracellular Ca 2+ homeostasis, disrupt normal energy metabolism, promote ROS accumulation, and ultimately lead to myocardial excitation-contraction dysfunction (169, 174)

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It is responsible for most biochemical functions like redox reactions and nucleophilic displacements, which are essential to carry out the detoxification of xenobiotics (Hasanuzzaman et al., 2017)
