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Pathology emerges focally and in discrete patches in the sulci of the neocortex, oftentimes in the superior and dorsolateral prefrontal cortex, but increasing in prevalence and spreading to temporal and parietal cortices as the degeneration progresses

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Protocol Documentation and Analysis Systematic documentation enables researchers to refine protocols and build upon previous findings

This study found that IN orexin-A administration essentially restores olfactory performance

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however, due to the small number of both randomized or observational trials, further research has to be conducted on the method (Manchikanti et al., 2013)