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Fourth, validation gaps persist, with 89% of proposed biomarkers lacking multicenter rigor

First, we performed a sensitivity analysis of l-carnitine or acetyl-l-carnitine supplementation on serum AST and ALT levels after excluding a study of patients with decompensated cirrhosis [31] (Figure S4)

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Changes in macrophage phenotype as the immune response evolves Curr Opin Pharmacol 13 4: 555-64

Diabetes Care 41(8):1717-25 2018 PMC6054504 RISE Consortium