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[DOI] [PubMed] [Google Scholar] 54.Sies H., Jones D.P

ACTL6A is found to be critical for regulating the glutathione (GSH) metabolism pathway because it upregulates -glutamyl-cysteine ligase catalytic subunit (GCLC) expression, thereby reducing reactive oxygen species (ROS) levels and inhibiting ferroptosis, a regulated form of cell death driven by the accumulation of lipid-based ROS

For pre and post subgroup, (MD = 1.26%, 95% CI [2.470.06], P = .04)

Note that the highest values indicating replacement of a residue into itself is for Trp and Cys

How long the effect lasts depends on what was in the bag

Therefore, ROS levels are reported as raw RLU to represent the total cumulative oxidative burden generated by the treatments within the niche