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The production of GPX4 and other selenoproteins is highly dependent on SEPHS2, and SEPHS2 has been shown to be a potential target for cancer therapy because of its important role in cancer cell survival

According to an estimate, around 1.2 million patients are diagnosed with colorectal cancer every year, and around 0.6 million die from it

However, free radicals also have indispensable physiological functions (e.g., acting as signaling molecules and regulating immune responses), and their deficiency may lead to health complications (Valko et al., 2007)

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