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While oral supplements are a common choice, they arent always effective if your body has trouble with absorption, making it difficult to get the full benefit

AGEs, which accumulate during the normal aging process, can be accelerated under diabetic conditions and may also be affected by diet

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Intramuscular (IM) hydroxocobalamin injections bypass the intrinsic factor-mediated absorption mechanism, delivering the entire dose directly into circulation

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As we alluded to earlier, cognitive control shares many processes and brain circuits that also are important for value-based decision making, and future studies are warranted to understand the role of opioids in these processes (Berkman, Hutcherson, Livingston, Kahn, & Inzlicht, 2017)