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It has been reported that CAR-T cell incorporation with 4-1BB, compared to CD28, indicated a significant reduction in the expression of inhibitory molecules, such as T cell immunoglobulin and mucin domain-containing protein 3 (TIM3), LAG-3, and PD-1 as well as the exhaustion-associated transcription factors

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[DOI] [PMC free article] [PubMed] [Google Scholar] 92.Velioglu O., Yildizgoren M.T., Ogut H., Guler H., Turhanoglu A.D

[DOI] [PubMed] 44.Nishida C, Ko GT, Kumanyika S

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