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Sutandy FXR, Gner I, Tascher G, Mnch C

The reason for this unexpected observation was that paralysis of an essential cellular defense mechanism like autophagy leads to faster accumulation of cellular waste, which triggers an enhanced rate of cell turnover through apoptosis and compensated enhanced regeneration [151]

[DOI] [PMC free article] [PubMed] [Google Scholar] 266.Huang Q

However, these parameters only detect functional impairment after significant renal damage has occurred, highlighting the need for more sensitive early biomarkers [5]

doi: 10.1159/000271917

doi: 10.1016/S0171-2985(98)80028-4 142 QiuYMarquez-CurtisLAJanowska-WieczorekA